| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells
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| Autores: |
YU,YING
JIANG,HAIFENG
NIU,YANGYANG
ZHANG,XIAOQIN
ZHANG,YINGYING
LIU,XI
QI,TAO
YU,CHEN
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| Data: |
2019-01-01
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| Ano: |
2019
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| Palavras-chave: |
Angiotensin II type 1 receptor blockers
Candesartan
Inflammation
Reactive oxygen species
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| Resumo: |
Abstract: Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor. In clinic, Angiotensin II type 1 (AT1) receptor blocker like candesartan has been widely applied as an antihypertensive medication. We previous have demonstrated that a higher dose of candesartan plays a protective role after kidney injury. However, whether candesartan could exhibit anti-inflammatory effects remains unclear. Here, by stimulating isolated human embryonic kidney epithelial cells with tumor necrosis factor-α (TNF-α), we observed the anti-inflammation capacity of candesartan ex vivo. It was found that pre-treat with candesartan significantly suppressed transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) expression after incubation with TNF-α. Surprisingly, silence of angiotensin II type 1 receptor has little effects on reducing TGF-β or IL-6 products. Furthermore, candesartan inhibited TNF-α-induced oxidative stress in the primary cultured tubular epithelial cells. Overall, our data indicates that candesartan suppresses TNF-α-induced inflammatory cytokine production by inhibiting oxidative stress, rather than block AT1 receptor activity.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300701
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201920180699
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.91 n.2 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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